Videos from the 2019 IPITA Congress
These videos are for meeting attendees only. All attendees were emailed their passwords. If you did not receive the email please do a password reset using the "Forgot your password?" link using the email address you used to register for the congress.
Login Form
Session 1 : Utility and utilization of the Igls criteria
- Click here for Session Details The Igls criteria: refresher
Michael RickelsApplication of the Igls Criteria: The UCSF Islet Experience
Yvonne KellyReal-life application of the criteria: Issues and comparative results (pancreas vs islets) - Reports from pancreas and islet transplant centers
Axel AndresPancreas transplantation alone versus islet transplantation alone: a comparison using the 2018 Igls criteria
Caterina ConteIPITA pre-congress workshop Real-life application of the Igls criteria
Michiel Nijhoff
Session 2 : Assessment and improvement of the Igls criteria
- Click here for Session Details Pre-transplant metabolic assessment of the patient
Michael RickelsHow can the Igls criteria be used to impact on patient management?
Peter Senior
Session 3 : Immuno monitoring of beta cell replacement
- Click here for Session Details Current immune monitoring practices
Peter StockSignificance of DSA monitoring of pancreas or islet grafts
Olivier ThaunatPancreas graft biopsy
Pablo Uva
Session 4 : Expanding the application of the Igls criteria
- Click here for Session Details Applicability to islet autotransplants
Melina BellinAssessing PTDM after beta-cell replacement
Eelco de KoningComparing transplants with artificial pancreas: what metrics?
Tom KayDefinition of success as a function of risk
Lorenzo Piemonti
Opening Ceremony
- Click here for Session Details Welcome
Xavier MartinWelcome
Thierry BerneyWhat is left of Claude Bernard in the Internet era ?
Pierre CorvolArtificial Intelligence in medicine: the good, the bad, the ugly
Christian Lovis
Opening the echo chamber - Perspectives on curing diabetes
- Click here for Session Details Panelist
Kate FarnsworthPanelist
Jonathan FridellPanelist
Frantisek SaudekPanelist
Tadej Batellino
Richard Lillehei lecture
- Click here for Session Details Introduction
Raja KandaswamyRichard Lillehei lecture
Angelika Gruessner
Symposium on islet xenotransplantation
- Click here for Session Details Clinical update of islet transplantation at the University of Chicago
Piotr WitkowskiChallenges of regulatory issues in islet transplantation
Barbara Barbaro
Oral 2 - Islet cell biology and beta-cell survival
- Click here for Session Details Withaferin A Attenuates Release of Exosomal Isletokines in Response to Islet ER Stress
P. SaravananStress-released miR 29b-3p+ and miR 216a-5p+ islet cell exosomes induce immune cell uptake and inflammatory gene response
S. VasuExosomal Signaling Between Alpha and Beta Cells
J. KalivarathanBiosynthetic activity differs between islet cell types and is modulated by glucose and other secretagogues
D. Cottet DumoulinRecombinant Nidogen-1 Significantly Improves Survival of Hypoxic Human Islets
D. BrandhorstAn inflammatory independent role for P65 (RELA) in insulin homeostasis
N.W. ZammitIslet protection by dimethyl fumarate in non-obese diabetic mice
S. LiEstablishing a whole pancreas biopsy collection protocol for the Quality in Organ Donation (QUOD) Biobank
M. Honkanen-Scott
Oral 1 - Clinical pancreas transplantation : graft assessment
- Click here for Session Details Contribution of early systematic CT-angiography in the follow up of patients with pancreatic allograft
H. YeContrast Enhanced Ultrasonography - A Novel Technique for Assessment of Allograft Perfusion in Early Post-Operative Period After Pancreas Transplant
J. Fridell18F-fluorodeoxyglucose positron emission tomography - computed tomography (18FFDG PET-CT) for diagnosing pancreas graft rejection and monitoring treatment response
C. ContePerformance of pancreas graft biopsies in the management of pancreas transplant recipients
F. BuronResults of kidney and pancreas biopsies performed at time of re-laparotomy during the first month after pancreas transplantation.
P. UvaQuantifiable loss of insulin secretory granules in protracted delayed endocrine pancreas graft function in comparison to controls
C. DrachenbergIncidence of sub-clinical graft rejection diagnosed in per protocol pancreas biopsy
P. Ventura-Aguiar
Pitch 1
- Click here for Session Details Peripheral blood T- and B-cells as predictors of acute rejection in pancreas transplant recipients
P. Ventura-AguiarEarly worsening of diabetic retinopathy after simultaneous pancreas and kidney transplantation?
B. VoglovaBMI is not Universally Predictive of Pancreas and Islet Lipid Content
A. FeeneyImpact of ischemia time on islet isolation success and post-transplantation clinical outcomes: a retrospective study on 452 pancreas isolations
C. WassmerInterferon-gamma increases the protein expression of the immunomodulatory marker HLA-E in human amniotic epithelial cells in vitro
F. LebretonIL-10 production by in vitro-expanded, human B cells
G. PerkinsDenovo Use of Once daily Extended release Tacrolimus (Envarsus XR) in Pancreas transplant recipients: A Single Center Experience
H. Shokouh-AmiriThe incidence of fungal infections in pancreas transplant recipients in the absence of systemic antifungal prophylaxis
S. Shaikh
Pitch 2
- Click here for Session Details Preservation of Pancreatic Islets with Stem Cell Derived CD34+ Vascular Endothelial Progenitor Cells
C. WardFracture risk in patients with type 1 diabetes undergoing remission through pancreas transplant alone
C. Conte3D Bioprinting of islets with adipose-derived stem cells into a scaffold improves islet function and survival
S. AbadpouriPSC from a patient with monogenic diabetes for autologous beta cell replacement
A. CospitoFormation of a Beta Cell Mass by Device-Encapsulated hiPS-Derived Pancreatic Endoderm Implanted in a Preformed Subcutaneous Pouch in Mice.
T. RobertEvaluation of usefulness of new devices aimed at development of bioartificial islet transplantation without immunosuppressant
K. AjimaNovel vascularization strategies to improve stem cell derived pancreatic progenitor engraftment for type 1 diabetes treatment.
Y. AghazadehProblems in realiziation of xenogenic or iPS cell-derived islet cell transplantation from the viewpoint of development of a new transplantation site
K. Inoguchi
Pitch 3
- Click here for Session Details Is there any Prognostic Value of Diabetes-Associated Autoantibody Levels for Predicting Islet Graft Function in Patients with Long-Standing Type 1 Diabetes Mellitus?
P. BachulInterest of Doppler Ultrasound in the diagnosis of vascular thrombosis after pancreatic allograft
H. YeEffect of undercarboxylated osteocalcin on β-cell function and survival after islet isolation using obese vb non-obese pancreas donor in a murine model of islet transplantation
MF. Desentis-DesentisIslet Surface Modification with Bissulfosuccinimidyl Suberate: A Novel Approach
J. KalivarathanAssessment of marginal islet graft function in the greater omentum and its viability in vivo by bioluminescence imaging in diabetic rats.
Z. HladikovaEx-situ hypothermic perfusion of non-human primates pancreas: an experimental model
T. PrudhommeExamining the Host Response to Cell Encapsulation Devices with 3D Printed Multiscale Porous Coatings.
RE. Levey
Pitch 4
- Click here for Session Details Single center surgical technique of motified Arterial Revascularization in Simultaneous pancreas-kidney transplantation
Y. FuA retrospective study of Simultaneous pancreas-kidney transplantation from a single center experience
Y. Fu
Mini Oral 1 - Islet transplantation
- Click here for Session Details Continuous Glucose Monitoring Metrics in Islet Transplant Recipients with Long-Term Insulin Independence
R. AlejandroIslet transplant outcomes in the integrated UK programme
P. JohnsonPresentation of the French TREPID group (Association pour la transplantation de pancréas et d’îlots dans le diabète) bringing together all the actors of the pancreas and islet transplantation in France.
L. BadetLong Term Renal Function Following Islet Transplantation in the Clinical Islet Transplantation (CIT) Consortium
M. RickelsThe impact of the introduction of clinical islet transplantation from brain-dead donors in Japan.
T. ItoClinical islet transplantation using marginal donors: a single-center experience
T. AnazawaIslet transplantation used to reinstate endogenous insulin production in a young woman with type 1 diabetes suffering from severe sub-cutaneous skin reaction to insulin
T. RadfordReduced Progression Of Diabetic Retinopathy In Type 1 Diabetes With Clinical Islet Transplantation Or Continuous Subcutaneous Insulin Infusion Compared With Multiple Daily Insulin Injections Over Three Years.
L. ReidThe impact of islet purity on metabolic outcome after islet transplantation via portal vein
G. YoshimatsuCharacterization of a modified Mandl collagen degradation activity assay for validating collagenase activity
RC. Mccarthy
Mini Oral 2 - Pancreas transplantation : technical aspects
- Click here for Session Details Pancreas after kidney transplantation with very small and young pediatric donor (17 months & 9 kg) with no arterial y graft
F. VistoliPancreas transplantation alone: functional and metabolic differences in portal vs systemic venous drainage
F. VistoliSingle center experience pancreas transplantation with a duodenoduodenostomy as exocrine drainage
K. LeeImpact of anatomical variations in intrapancreatic veins on prevention of venous thrombosis following pancreas transplantation
K. KitajimaFence angioplasty prevents narrowing of venous anastomosis in solitary pancreas transplant
B. ChoiDouble arterial reconstruction of the pancreatoduodenal arcade in pancreas transplantation
M. PerosaExperiences of pancreas transplantation from pediatric brain-dead donors in our hospital.
K. KuriharaGastric Per-Oral Endoscopic Pyloromyotomy (GPOEM) after pancreas transplant – first report
J. FridellComparison of Liposomal Bupivacaine with Continuous Catheter Infusion for Transversus Abdominis Plane Block Analgesia in Pancreas Transplant Patients
J. Fridell
Mini Oral 3 - (Bio)artificial pancreas and stem cells
- Click here for Session Details A novel fully-implantable artificial pancreas: site of implant and operational functionality in real human anatomy
F. VistoliTOWARDS 3D-BIOPRINTING OF BIONIC PANCREAS: Influence of the bioink composition during 3D bioprinting of pancreatic scaffolds on the functionality and viability of pancreatic islets.
M. WszołaTowards 3D-bioprinting of bionic pancreas: the effect of time of UV crosslinking on pancreatic islets after the bioprinting process.
M. GomółkaTowards 3D-bioprinting of bionic pancreas: effect of pressure on the viability of pancreatic islets.
P. KowalskaPancreas decellularization protocol - balance between low DNA concentration and structural damage as a condition of successful recellularization.
A. BermanThe influence of the flow of detergent and donors characteristic on the extracellular matrix composition after human pancreas decellularization.
A. BermanBio artificial endocrine pancreas generated from decellularized human placenta for type-1 diabetes treatment
Fanny LebretonEncapsulation improves differentiation of the human induced pluripotent stem cells towards insulin-producing cells
L. GhilaCo-microencapsulation of human adult mesenchymal stem cells and monolayered islet cells as a hybrid organ to treat type 1 diabetes mellitus (T1D)
G. BastaDevelopment of New Polyethylene Glycol (PEG) Micro-Bulk Encapsulation Product for the Immuno-Isolation of Human Islets
D. Scharp
Mini Oral 4 - Clinical and preclinical beta-cell replacement
- Click here for Session Details Regional Differences of Islet Distribution in Cynomolgus Monkey
D. ShinThe Minimum Islet Number Required for Insulin Independence in Cynomolgus Monkeys After Islet Allotransplantation
GS. KimWhole Pancreatic Extracellular Matrix Protects Isolated Human Islets from Hypoxia-derived Damage
D. BrandhorstA single-center initial experience using Institut Georges Lopez-1 (IGL-1) solution in clinical pancreas transplantation
J. FerrerPhysical Activity after Transplantation in Pancreas Transplant Recipients
Y. KudvaCurrent Results After Pancreas Transplantation in Norway
R. HornelandCurrent status of pancreas transplantation in Japan – Registry report from Japan Pancreas and Islet Association (JPITA)
T. KenmochiPancreas transplantation in Brazil: a tendency of decline contrasting to a single-center increase
M. PerosaKEEPING THE FLAME BURNING Maintenance of a High-Volume Pancreas Transplant Program in Times of Crisis
M. Perosa
Biotechnology shapes the future for beta cell replacement therapy
- Click here for Session Details “House of islets”
Lorenzo PiemontiBioengineering approach to immunosuppression-free islet transplantation
Haval ShirwanGeneration of organoids from human pancreatic cells
Eelco de Koning
Organ preservation « Out of the box »
- Click here for Session Details Sorting criteria for the marginal pancreas: waste or recondition ?
Raja KandaswamyNormothermic regional perfusion of pancreas and islet donors
Andrew SutherlandHypothermic oxygenated machine perfusion in pancreas/islet transplantation
Vassilios PapaloisOxygen persufflation : a feasible and efficient technique for pancreas reconditioning ?
Klearchos Papas
Oral 3 - Clinical islet allotransplantation
- Click here for Session Details Relative Stabilization of Cardiovascular Disease Markers after Islet Cell Transplantation in Patients with Type 1 Diabetes in the Clinical Islet Transplantation (CIT) Islet Alone and Islet After Kidney Pivotal Trials
KK. DanielsonIgls criteria applied to the Australian islet transplant program.
T. KayValidation of the IGLS-score by continuous glucose monitoring, a new tool for evaluating the function of transplanted beta cells
M. ChetbounPeri-transplant glycaemic control does not predict 3-month islet transplant graft function
I. ShapeyIslet Transplantation vs. Standard of Care for Type 1 Diabetes Complicated by Severe Hypoglycemia from the Collaborative Islet Transplant Registry (CITR) and the T1D Exchange (T1DX) Registry
M. RickelsThe impact of pancreas and islet transplantation on quality of life: a systematic review
I. MoscaPublic Coverage of Islet Transplantation for Eligible Candidates: A Study Mandated by Québec’s Ministry of Health and Social Services
M. GasparriniTNF-alpha blockade during islet transplantation in immunosuppressed recipients
M. NijhoffPancreatic Islet Transplantation in Type 1 Diabetes; A Randomized, Double Blinded Trial of the CXCL8-inhibitor Reparixin
L. Piemonti
Oral 4 - Pancreas procurement and preservation
- Click here for Session Details Preliminary results on the effect of HEMO2life®, a marine oxygen carrier, on human pancreases cold preservation
F. LemaireHypoxic Preconditioning Reduces Ischemia-induced Damage of Isolated Rat Islets
D. BrandhorstNormothermic regional perfusion (NRP) NRP
G. DefriesRevising the UK National Pancreas and Islet Offering Scheme
J. CaseyA two-year cohort study of access to a local pancreas retrieval hospital in France
S. KharchenkoOptimising the donor pancreas selection process using hierarchy based decision trees
I. ShapeyNew trends in preservation solutions: Institut Georges Lopez-1 (IGL-1) for improvement of current clinical standards of pancreas preservation
J. Ferrer
Oral 5 - Immunosuppression
- Click here for Session Details Thymoglobulin Efficacy: The Role of Dosing on Infection and Rejection in Pancreas Transplantation
H. SarumiEfficacy of everolimus with reduced-dose Mycophenolate Mofetil in pancreas transplant patients
A. KawaiTacrolimus versus Sirolimus as cornerstone immunosuppression after simultaneous pancreas and kidney transplantation: 5-year results of an open label, non-inferiority, randomized controlled trial.
D. CantarovichSirolimus versus mycophenolate mofetil (MMF) in primary combined pancreas and kidney transplantation. Results of a long-term prospective randomized study
F. SaudekInitial experience with Belatacept in Pancreas Transplantation
P. UvaImpact of a CNI-free immunosuppressive regimen on donor specific antibodies, histology and rejection, following simultaneous pancreas and kidney transplantation
D. CantarovichCell-Selective Immunosuppression Enhances Allogenic Islet Transplantation
J. BurkeExperience with alemtuzumab induction with tacrolimus/mycophenolate ± steroids in simultaneous pancreas-kidney transplant recipients with portal-enteric drainage
Guiseppe OrlandoTen Year Results of a Single Center Study of Rabbit Anti-Thymocyte Globulin Compared to Alemtuzumab Induction in Simultaneous Pancreas-Kidney Transplantation
Guiseppe Orlando
Oral 6 - Regenerative medicine
- Click here for Session Details Proteomic Characterization of the Human Pancreatic Matrisome
G. OrlandoNovel water-based, detergent-free decellularization to produce bioactive ECM-based scaffolds for pancreatic islets transplantation
R. TamburriniGeneration of mature β-cells from human pluripotent stem cells in vitro
G. NairInsulin producing cells derived from induced pluripotent stem cells (iPSC): a comparison with human islets
S. PellegriniBioengineering of an iPSC derived vascularized endocrine organ for T1D
A. CitroBiofabrication of a Vascularized Islet Organ for Type 1 Diabetes
A. CitroIslets loaded in hydrogel derived from human amniotic membrane reverse diabetes in SCID mice
K. BellofattoShielding islets with human amniotic epithelial cells protects islets against hypoxia and enhances islet engraftment and revascularization after transplantation in a murin diabetic model.
F. LebretonPancreatic ECM co-culture enhances phenotypic maturity of stem cell-derived beta cells
D. Tremmel
Hypes and hopes of the artificial pancreas
- Click here for Session Details Current automated insulin delivery systems : what do they really achieve ?
Alanna WeismanPatient-driven R&D : why-how-what ?
Kate FarnsworthComparison of the DBLHU Closed-Loop Insulin Delivery with Low-Glucose-Predictive-Suspend system in adults with very unstable type 1 diabetes: A Feasibility and Safety trial
Pierre Yves BenhamouRisk-benefit assessment of beta-cell replacement vs automated insulin delivery systems
Patrik Choudhary
Presidential address/Derek Gray Awards
- Click here for Session Details Introduction
J. MARKMANNThe future of beta-cell replacement is now !
Thierry BerneyNWZ Derek Gray Award update
Nathan Zammit
Oral 7 - Clinical pancreas transplantation : metabolic and cardiovascular outcomes
- Click here for Session Details Pancreas transplantation alone with portal vs systemic venous drainage: a propensity score matching comparison
F. VistoliPancreas transplantation alone versus islet transplantation alone: metabolic outcomes and perioperative complications
C. ConteAnalysis of the skeletal muscle mass in simultaneous pancreas and kidney transplantation patients
N. AidaAssessment of insulin sensitivity in pancreas and islet transplant recipients
C. WassmerImpact of pancreas transplantation on bile acids, incretins and glucose metabolism.
C. FournieImpact of simultaneous pancreas-kidney transplantation on post-transplant major adverse cardiovascular events in type 1 diabetic patients with end-stage renal disease
P. Ventura-AguiarSymptomatic Coronary Artery Disease after Simultaneous Kidney-Pancreas Transplantation
R. KnightNeurogenic orthostatic hypotension: an iatrogenic complication of successful pancreas transplantation?
RJ. KnightOutcomes after Pancreas Transplantation Alone based on Pre-transplant CMV and EBV Serology Status
Y. Kudva
Oral 8 - Clinical islet allotransplantation
- Click here for Session Details 45-Year Experience with Allo-Islet Transplantation.
J. HarmonChallenges to effective long-term follow-up after islet transplantation in a large transplant centre with an expanding recipient cohort.
C. IbbotsonIslet transplantation within the NHS program is associated with reduced fear of hypoglycaemia and improved diabetes-specific quality of life
A. FlattBETA-2 Based On Single Fasting Blood Sample Allows To Define and Discriminate Optimal And Suboptimal Islet Allograft Function Prior to The Need For Reintroduction of Insulin Support.
P. BachulIn vivo quality control of human islets in 165 immunodeficient mice to predict islet function in man: a retrospective study in 87 clinical transplants.
J. Kerr-ConteImportance of insulin content on insulin secretion during islet evaluation
V. GmyrDifferences by Recipient and Donor Sex in Clinical Outcomes Following Islet Cell Transplantation for Type 1 Diabetes
KK. DanielsonStable Graft Function and Glycemic Control after Clinical Islet Transplantation on the Omentum
R. AlejandroPancreas donation after euthanasia – a suitable islet source for transplantation?
A. Steffen
Oral 9 - Islet xenotransplantation
- Click here for Session Details IgM immunotherapy for islet allo and xeno tolerance induction.
K. BraymanConsistent long-term porcine islet survival in nonhuman primates (NHPs) using a clinically available immunosuppression regimen
CG. ParkUse of oxygen consumption rate dynamics to establish a metabolic profile of porcine islets after injury
Z. SwansonDevelopment of Young Porcine Islet maturation in vitro monitoring by Helper dependent Adenovirus carrying INS-Venus
Y. Yamashita-SugaharaOptimisation of an adeno-associated virus gene delivery into neonatal porcine islets
N.W. ZammitPrenatal Porcine Pancreas as Source for Islet Cell Grafts
I. De Mesmaeker
Oral 10 - Islet graft assessment and monitoring
- Click here for Session Details A new molecular quality control: NKX6.1 gene expression predicts human beta cell potency in nude mouse bioassay and men.
J. Kerr-ConteSemi-automated analysis of human islet viability demonstrates better correlations with transplantation outcomes over manual viability assessment in a diabetic mouse model
H. KomatsuDifferentially methylated cell‐free DNA monitoring in pancreas transplant recipients with functioning graft
P. Ventura-AguiarSignificance of Hypoxia and Inflammation-Mediated Stress Specific Peritransplant Exosomal MiRNAs in Islet Transplantation
P. SaravananFibroblast Growth Factor-21 as a marker of islet function after transplantation
R. MeierThe novel “Glucose-Dependent Insulin Secretion Rate” (GDISR) detects a time-dependent deterioration in islet graft function following first transplant
RM. SpiersLacripepTM and its analogs promote islet viability and enhance insulin secretion – A novel approach as an interventional agent to promote islet graft survival?
K. BraymanA promising strategy for ameliorating the islet allograft engraftment; “pre-conditioning” islet cells by mitomycin-C
K. YamaneThe use of FreeStyle Libre Flash Glucose Monitoring System to monitor Blood Glucose Levels in Large Animal Porcine Model.
D. Penko
Mini Oral 5 - Pancreas transplantation: outcomes and complications
- Click here for Session Details Does the cause of primary graft failure affect long term results in pancreas re-transplantation ?
J. FerrerMay Kidney Donor Profile Index (KDPI) become the pancreas predictive factor after simultaneous pancreas-kidney transplantation from marginal donors?
S. MiyagiProgression of Peripheral Vascular Disease after Kidney/Pancreas (KP) Transplantation
R. KnightSudden blindness as an early complication of pancreas transplantation
A. AndresEndovascular management of vascular complications following pancreas transplantation
J. BranchereauArterio-enteric fistulae complicating failed pancreatic grafts: A case for prophylactic transplant pancreatectomy?
S. CotteeDonor-Derived Cell-Free DNA for surveillance in Simultaneous Pancreas and Kidney Transplant Recipients, can we extrapolate from Kidney Transplant Alone?
O.K. OlaitanCharacterization of Metabolism in Pancreas Transplant Recipients.
Y. KudvaLate pancreas allograft failure due to diabetes recurrence following SPK transplantation
D. Cantarovich
Mini Oral 6 - Immunology and graft rejection
- Click here for Session Details What factors most influence the high immunological graft loss rate in young recipients of a pancreas transplants alone ?
A. GruessnerImpact of an immunosuppressive regimen on maintaining long-term insulin independence from islet allograft: retrospective study of 43 patients in Lille
M ChetbounKidney function and metabolic parameters after simultaneous pancreas and kidney transplantation: results of a prospective and randomized study comparing Tacrolimus versus Sirolimus
D. CantarovichRelationship between histological rejection status and glucose metabolism in pancreas graft recipients
T. HavrdovaEvolution of Interleukin 7, Body Composition and Metabolic Profile Before and After Islet Transplantation
E. VernotteFunctional Immune tolerance following islet cell transplant with alemtuzumab induction: A case study
K. DuncanSirolimus de Novo and Flexible PCR Cutoff Interpretation in Pancreas Transplant Recipients Receiving No Pharmacological Prophylaxis for Cytomegalovirus Infection Minimizes The Need of CMV Treatment
M. PerosaDevelopment of a novel immunosuppression-free cell device for pancreatic islet transplantation
M. GotoEstablishment of islet allograft acceptance by mitogen-activated protein kinase kinase via suppression of alloreactive T cells
S. Tada
Mini Oral 7 - Islet autotransplantation
- Click here for Session Details Quantitative Analysis of Microbial Contamination in Islet Isolation for Total Pancreatectomy and Islet Auto Transplantation (TPIAT): Development of Bioburden Reduction Strategies
Z. SwansonAssessment of Four Metabolic Testing Protocols to Estimate Islet Number and Mass in Adults Undergoing Total Pancreatectomy with Islet Autotransplantation
M. BellinAdvanced Genetic Testing as an Adjunct to Clinical Decision-Making in TPIAT: A Case Report
M. LevyEndocrine Cell Identity in patients with Chronic Pancreatitis Undergoing Islet Autotransplantation
O. SabekImpact of Sarcopenia on Total Pancreatectomy and Auto Islet Transplantation in Chronic Pancreatitis Patients
R. ShahbazovThe Effect of Tobacco Use and Disability Status on Surgical Outcomes Following Total Pancreatectomy with Islet Autotransplantation
B. GutamaThe First Report of Total Pancreatectomy and Islet Cell Auto-transplantation for Pancreatic Cystosis in Patient with Cystic Fibrosis
C.S. DesaiCOMPARISON OF PANCREATA AND ISLET PREPARATIONS FROM HUMAN ORGAN DONORS - Influence of family history of diabetes or marginal levels of HbA1C
T. Loudovaris
Mini Oral 8 - Experimental beta-cell replacement
- Click here for Session Details Characterisation of novel porous membranes for Beta-cell encapsulation
R. BeattyFeasibility of islet transplantation into device-less subcutaneous implant site with co-administration of a necrosis inhibitor
H. KimIslet Encapsulation with Tannic Acid Suppresses Chemokine Production and Prolongs Graft Function
J. BarraKeratinocyte Growth Factor-Releasing Particles Enhance Islet Engraftment and Improve Metabolic Control in a Model of Type 1 Diabetes in Mice
S. ForbesSpheroid engineering for 3D cell culture: which method to choose?
C. WassmerImproving β-cell function by co-culturing with human umbilical vein endothelial cells and amniotic epithelial cells
C. WassmerHuman Amniotic Epithelial Cells and Amniotic Membrane as a Vehicle for Islet Transplantation
W. CuiMesenchymal stem cell-derived exosomes attenuates hypoxia-induced islets damage
E. LeeThe effect of NecroX-7 on islets against oxidative stress and inflammation
H. LeeIs a local release of insulin from islet graft crucial for liver impairment?
J. Kriz
Type 2 diabetes: a surgical disease ?
- Click here for Session Details Bariatric surgery : reviving the failing beta cells in type 2 diabetes
Sayeed IkramuddinPancreas transplantation : replacing the failing beta cells in type 2 diabetes
Jon S. Odorico
Letter to the (gene) editor
- Click here for Session Details Genome editing made easy (« Genome editing for dummies » ?)
Danwei HuangfuWill gene editing carry pig islets to the clinic ?
Eckhard WolfCan genome editing produce "universal human cells" for transplantation ?
Gregory Block
Oral 11 - Clinical pancreas transplantation : outcomes and complications
- Click here for Session Details Pancreatic Thrombosis with ultra-short graft vein technique: a single –center experience
F. DanzierePossibilities of interventional radiology in pancreas transplantation complications
A. Surowiecka-PastewkaMinimizing rates of technical graft loss, reoperations and hospital stay in pancreas transplantation. An evolutive analysis
M. PerosaPancreas Transplantation in the Elderly Patient - What do they Gain?
A. GruessnerLong-term Pancreas Graft Function – What can we expect in the Future?
A. GruessnerContinued improved outcome after simultaneous pancreas kidney transplantation despite low case load. A single center cohort.
D. Monbaliu
Oral 12 - Islet isolation
- Click here for Session Details Donor age-related differences in the digestibility of key pancreatic extracellular matrix proteins may help to explain poorer islet isolation outcomes from younger human donors
RM. SpiersRole of protease in digesting peri-islet basement membrane for the release of mantle free islets from young donor pancreases
G. LoganathanInfluence of collagenase activity dosing on the outcome of clinical islet isolation
A. FribergComparison of Collagenase Sources for Maximal Recovery of Human Islet Equivalents (IEQ)
D. ScharpShould we return to adjusting collagenase dosage to account for pancreas weight?
S.J. HughesComparing islet isolation from non-diabetic donors with and without islet autoantibodies
C. LiuUtilization of an "old school" supplemental purification technique allowed safe intraportal pancreatic islet transplantation. The first case of islet allotransplantation in Medical University of Gdańsk, Poland.
J.E. GolebiewskaValidation of a Completely Closed, Continuous Islet Isolation Machine for Islet Autotransplantation by a Microsphere Model
J. DoppenbergIsletNet: an Online Service for Standardized Islet Counting
D. Habart
Oral 13 - Islet engraftment and extra-hepatic implantation sites
- Click here for Session Details Parathyroid CD34+ cells induce neovascularization from donor and recipient leading to chimeric vessel formation and improved engraftment of co-transplanted pancreatic islets
Y. KellyIlluminating brown adipose tissue as a novel site for islet transplantation
J. KepplePilot Study on Pancreatic Islet Cell Implantation in Omentum of Type 1 Diabetes Patients
F. Van HullePre-transplant intermittent normobaric oxygen inhalation therapy to recipients increases vascularity of subcutaneous graft beds and improves engraftment in rat islet transplantations
H. KomatsuSandwiching islets using clinically proven, biodegradable mesh to mitigate hypoxic damage in subcutaneous islet transplantation
H. KomatsuA novel type of intraperitoneal islet transplantation named “rolling-up method using epididymal adipose tissue”.
N. SakataDoes A CXCR1/2 Inhibitor (Reparixin) Improve Islet Cell Engraftment And Clinical Outcomes After Pancreatic Islet Allotransplantation In Patients With Type 1 Diabetes Mellitus? Results of A Randomized, Double Blind, Prospective Study from the University of Chicago.
P. BachulReduction in islet requirement for diabetes cell therapy: Preclinical study
E. Maillard
Oral 14 - Experimental beta-cell replacement
- Click here for Session Details BMP-dependent SMAD-FOXO1 transcriptional synergy is a critical mechanism of tacrolimus-associated human ß-cell failure
APJ. De VriesSteroidal lactone Withaferin A prolongs islet allograft survival by modulating immune response toward protective T cell subsets
K. KUMANOFucoidan Enhances the Function and Reduces Apoptosis of Mouse Islets
H. JangInnate immune sensing and tissue remodelling of a biodegradable tempering matrix supported islet graft.
S. WaltersReconstructing the in vivo niche for improved islet culture and transplantation
D. TremmelOptimization of ColG:ColH ratio to establish donor tissue specific islet isolation
Y. Miyazaki3D imaging analysis of islet changing after transplantation by organ transparentization
K. ShinoharaRaman Microspectroscopy: a powerful tool for understanding donor age-related differences in extracellular matrix protein digestion during human islet isolation
RM. SpiersHigh-throughput proteomics to characterise donor age-related changes in the extracellular matrix of the human pancreas
RM. Spiers
Keeping an eye on beta cells : biomarkers to monitor pancreas and islet grafts
- Click here for Session Details An Intra-cutaneous alternate transplantation site for islet transplantation
Toby CoatesImmune monitoring of signs of rejection and diabetes recurrence
Paolo MontiGenomics of beta cell death
Bashoo Naziruddin
Immunosuppression tailored for beta-cell replacement
- Click here for Session Details Immunometabolism and beta cell replacement
Marc DonathStrategies for beta cell replacement: Pancreas vs Islet
Peter StockPrecision medicine in immunosuppression: how hard can it be ?
Dorry SegevTolerance induction in beta cell replacement
Qizhi Tang
Paul Lacy Lecture
- Click here for Session Details Introduction
Lorenzo PiemontiPaul Lacy Lecture
Antonio Secchi
Oral 15 - Islet autotransplantation
- Click here for Session Details Islet auto-transplantation after pancreatic cancer surgery
F. VistoliA Large Administrative Claims Database Analysis of Costs and Patient Demographics Associated With Total Pancreatectomy with Autologous Islet Cell Transplantation
C.S. DesaiRisk Factors Associated with Progression Towards Endocrine Insufficiency in Chronic Pancreatitis
B. GutamaFibrosis scoring of resected pancreas to predict islet transplant outcomes in patients undergoing TPIAT: A retrospective cohort study
K. KUMANOA Randomized and Blinded Trial of Infusion of the CXCL8-inhibitor Reparixin in Autologous Islet Transplant Recipients
M. BellinPancreas Transplantation for Chronic Pancreatitis Following Total Pancreatectomy
J. Fridell
Oral 16 - Clinical pancreas transplantation : graft survival
- Click here for Session Details Patient survival advantage of kidney-pancreas over kidney alone at listing or transplant
E. FingerIn the new era of pancreas transplantation: Are there immune or non-immune factors that determine the short or long-term graft survival rates of PAK vs SPK transplants?
M. LaftaviPortal-Endocrine and Gastric-Exocrine Drainage Technique in Pancreatic Transplantation
H. Shokouh-AmiriLong-term outcomes of pancreas-after-kidney and islet-after-kidney transplantation
M. NijhoffExperience of conseccutive 400 cases of pancreas transplantation in a single center in Korea
Y. Kim
Oral 17 - Transplant immunology
- Click here for Session Details Eosinophil to monocyte ratio is the strongest indicator of acute cellular rejection in pancreas transplant alone recipients.
B. ChoiImmunoengineering of human stem-cell-derived insulin-producing cells for transplantation
G. FaleoCCL2/MCP1 and CXCL12/SDF-1 blockade by Spiegelmer improves pancreatic islet engraftment and survival in mouse
A. CitroKRP-203 as a desirable immunomodulator for islet transplantation
I. Fathi
Oral 18 - Experimental beta-cell replacement
- Click here for Session Details Pseudo-islets gearing up for the clinics : feasibility, reproducibility, residual donor signature?
A. VaissiéAssessment of a novel hydrogel to replace extracellular matrix lost in isolated islets prior to transplantation: impact of collagen/alginate/fibrin hydrogel on islet morphology, viability and function
N. KattnerGeneration of ß cells from iPSC: the contribution of human pancreatic mesenchymal and endothelial cells
M.T. LombardoImproved Human Islet Function and Survival When Culturing with a cGMP Human Growth Factor Product
G.L. SzotMacro encapsulation of functional hESCs-derived insulin producing cells.
K. MolakandovAssessment of 3D-Bioprinted Human Regulatory T-cells using IL-2 and CCL1 Supplemented Alginate-GelMA Bioink
J. Kim
Dinosaur Challenge
- Click here for Session Details Battle 1: Why have we not yet achieved immunological tolerance? Are you fooling us, or are you fooling yourselves!
Nathan ZammitBattle 1: Why have we not yet achieved immunological tolerance? Are you fooling us, or are you fooling yourselves!
Alice KoenigBattle 1: Why have we not yet achieved immunological tolerance? Are you fooling us, or are you fooling yourselves!
Shane GreyBattle 1: Why have we not yet achieved immunological tolerance? Are you fooling us, or are you fooling yourselves!
Qizhi TangBattle 2: You dinosaurs will be considered butchers for doing pancreas transplants in the near future!
Julien BrancherauBattle 2: You dinosaurs will be considered butchers for doing pancreas transplants in the near future!
Raphael MeierBattle 2: You dinosaurs will be considered butchers for doing pancreas transplants in the near future!
Peter StockBattle 2: You dinosaurs will be considered butchers for doing pancreas transplants in the near future!
Jon OdoricoBattle 3: Islet transplantation will be extinct, like you dinosaurs, before its full potential is realized!
Adriana MiglioriniBattle 3: Islet transplantation will be extinct, like you dinosaurs, before its full potential is realized!
Christian SchuetzBattle 3: Islet transplantation will be extinct, like you dinosaurs, before its full potential is realized!
François PattouBattle 3: Islet transplantation will be extinct, like you dinosaurs, before its full potential is realized!
Eelco de Koning
Beta cell grafts for all
- Click here for Session Details Novel immunomodulatory approaches for porcine islet xenotransplantation
Chung Gyu ParkOrgan manufacturing by interspecies blastocyst complementation
Juan Carlos Izpisua BelmonteChallenges and opportunities of hESC-derived β cells for T1D therapy
Cristina NostroRe-create beta cell development in a dish – a source for future cell therapy
Henrik Semb
PITCH presentation finals
- Click here for Session Details PITCH #4
I. ShapeyPITCH #1
C. WassmerPITCH #1
S. ShaikhPITCH #2
C. WardPITCH #2
T. RobertPITCH #3
T. PrudhommePITCH #3
MF. Desentis-DesentisPITCH #4
A. Surowiecka-Pastewka